時間(Time)：14:30-16:30 PM, October 22 (Wednesday), 2025
地點(Place)：Lecture Hall R1-B1222
講者(Speaker)：Prof. Dr. h.c. N. Jon Shah
Abstract
Over the past four decades, MRI has become an essential tool for visualising the structure and function of the human brain, both in vivo and post mortem. Recent developments have advanced the field toward ultra-high-resolution structural imaging and layer-specific functional MRI. In parallel, MRI has steadily expanded into metabolic imaging, offering new insights into brain physiology.
A central research area is the integration of MRI and PET in a hybrid MR-PET system capable of acquiring both datasets simultaneously. This powerful combination opens up new possibilities in both basic and translational neuroscience by enabling a deeper understanding of molecular and metabolic processes in the brain.
In this presentation, I will focus on the rationale for multimodal, multi-dimensional MRI. I will introduce EPIK (echo planar imaging with keyhole), a sequence developed at our institute that enables whole-brain, layer-specific fMRI with an isotropic voxel size of 0.6 mm. I will also present a multi-echo version of EPIK that allows measurement of the oxygen extraction fraction in the human brain, along with potential applications and first results.
These advances illustrate the value of combining structural and functional MRI with complementary metabolic and molecular imaging approaches—such as those enabled by X-nuclei MRI and PET. In this context, simultaneous MR-PET systems, such as the BrainPET-7T insert, provide a unique platform for in vivo investigations of energy metabolism and neurotransmitter systems. These possibilities will be explored further in the presentation.
Short Biography
Prof. Dr. h.c. N. Jon Shah is Director of the Institute of Neuroscience and Medicine – 4 at the Forschungszentrum Jülich, Germany, where the primary focus is the development and implementation of innovative MRI methods and sequences, particularly for brain imaging. Under his leadership, the institute conducts cutting-edge research in areas including quantitative MRI, structural and functional imaging, sodium imaging, diffusion imaging, metabolic imaging, multimodal approaches, and ultra-high-field MRI. These efforts are supported by the in-house design and construction of specialist imaging hardware.
Professor Shah’s research is dedicated to advancing brain imaging through novel MRI methodologies. His work spans from the conceptualisation and technical realisation of new imaging technologies to their application in addressing critical questions in neuroscience. A central focus of his research is the integration of MR-PET systems, enabling the simultaneous acquisition of structural, functional, metabolic, and molecular data. This multimodal strategy opens new avenues for exploring complex brain processes and supports both fundamental research and clinical translation.
