Chia-Hsien Hsu

Chia-Hsien Hsu

Chia-Hsien Hsu, Ph.D.

Investigator

Office ext. 37105

Lab ext. 37143

chsu

Lab website.

Education

  • 2001-2006
    University of Washington, Seattle, WA., USA
    Ph.D. in Mechanical Engineering
  • 1997-1999
    National Chung Cheng University, Chia-Yi, Taiwan
    M.S. in Mechanical Engineering
  • 1993-1997
    National Chung Hsing University, Taichung, Taiwan
    B.S. in Mechanical Engineering

經歷

  • 2022-present
    Institute of Biomedical Engineering and Nanomedicine, NHRI, Taiwan
    Investigator
    2016-2022
    Institute of Biomedical Engineering and Nanomedicine, NHRI, Taiwan
    Associate Investigator
    2016-present
    Institute of NanoEngineering and Microsystems, NTHU, Taiwan
    Adjunct Associate Professor
    2022-present
    Ph.D. Program in Tissue Engineering and Regenerative Medicine, NCHU, Taiwan
    Adjunct Professor
    2009-2016
    Division of Medical Engineering Research, NHRI, Taiwan
    Asisstant Investigator
    2006-2009
    Harvard Medical School, Massachusetts General Hospital and Shriners Hospital for Children, Boston, MA., USA
    Postdoctoral Research Fellow

Research Interests

Microfluidics, BioMEMS, Organ-on-chip, Point-of-care diagnostics, Tissue engineering, Regenerative medicine.

Honors and Awards

    1. 國科會自動化學門112年度成果發表會最佳海報獎優等
    2. 2023 NHRI Research Achievement Award (國家衛生研究院112年度傑出學術成就獎)
    3. 2022 National Innovation Award (2022年度國家新創精進獎)
    4. 科技部工程司110年度產學計畫成果簡報優良獎
    5. 2021 National Innovation Award (110年第十八屆國家新創獎創新醫材與診斷技術類─續獎)
    6. 科技部工程司109年度產學計畫成果簡報特優獎
    7. 2020 National Innovation Award (109年第十七屆國家新創獎創新醫材與診斷技術類─續獎)
    8. 2020 Taipei Biotech Awards-Technology Transfer Award (2020年台北生技獎技轉合作優等獎)
    9. 2019 National Innovation Award (108年第十六屆國家新創獎創新醫材與診斷技術類─續獎)
    10. 2018 National Innovation Award (107年第十五屆國家新創學研新創獎)
    11. 2017 National Innovation Award (106年第十四屆國家新創學研新創獎)
    12. 科技部工程司106年度產學計畫成果簡報優良獎
    13. 2017 NHRI Young Scientist Research Achievement Award (國家衛生研究院106年度年輕學者學術成就獎)
    14. MOST Young Scholar Fellowship 2017-2019 (科技部優秀年輕學者研究計畫專題補助)

Papers (2016-present)

  1. Yun-Chen Wu and Chia-Hsien Hsu, “Engineering PDMS membranes with tunable biomimetic curvatures: from partial curing to vacuum-induced shaping”, Materials & Design 264 115816, (Mar. 9th. 2026). (Ranking: 88/461, Q1, I.F.= 7.900, Material Science, Multidisciplinary). Corresponding Author
  2. Hui-Ying Lin, Jing-Yi Yang, Hao-Chen Chang, Ing-Ming Chiu, Horng-Dar Wang and Chia-Hsien Hsu, “MyelinoChip: A Myelination-on-a-Chip Platform with Suspended High Aspect-Ratio Microfibers for Long-Term Tracking of Myelin Sheath Formation”, Biomedical Materials 20 065031, (Nov. 28th. 2025).. (Ranking: 51/124, Q2, I.F.= 3.700, Engineering, Biomedical). Corresponding Author
  3. Guan-Ting Li, Chia-Hsien Hsu, ,Bhupendra Pratap Singh and Shug-June Hwangun, “Reversible photomechanical actuators with liquid crystal polymer graphene oxide nanocomposites”, Journal of Materials Chemistry C (Nov. 26th 2024). (Ranking: 35/179, Q1, I.F.= 5.700, Physics, Applied).
  4. Pei-Tzu Lai, Cheng-Kun He, Chi-Han Li, Jefunnie Matahum, Chia-Yu Tang, Chia-Hsien Hsu, “The hanging-heart chip: A portable microfluidic device for high-throughput generation of contractile embryonic stem cell-derived cardiac spheroids”, Bioengineering & Translational Medicine 2024;e10726. doi:10.1002/btm2.10726, (Oct. 08th 2024). (Ranking: 20/122, Q1, I.F.= 6.100, Engineering, Biomedical). Corresponding Author
  5. Yun-Chen Wu, Jing-Yi Yang, and Chia-Hsien Hsu, “Tape-assisted fabrication method for constructing PDMS membrane-containing culture devices with cyclic radial stretching stimulation”, Royal Society Open Science 11 (8) 240284, (Aug. 14th 2024). (Ranking: 37/136, Q2, I.F.= 2.900, Multidisciplinary Sciences). Corresponding Author
  6. Duane S. Juang, Yi-Ren Hou, Hsin-Kai Tseng, Chih-Chen Chen, Chia-Hsien Hsu, Chun-Cheng Lin, “A Microfluidic Countercurrent Reactor for Accelerating Enzymatic Reaction”, ChemCatChem 148 (15), 3045-3056, (Jul. 13rd, 2023). (Ranking: 63/161, Q2, I.F.= 4.500, Chemistry, Physical)
  7. Yu, Lin-Yen, Chia-Hsien Hsu, Chia-Yang Li, Shiao-Ya Hong, Chaang-Ray Chen, Chi-Shuo Chen, “Evaluating the biological effectiveness of boron neutron capture therapy by using microfluidics-based pancreatic tumor spheroids”, Analyst 148 (13), 3045-3056, (Jun. 26th, 2023). (Ranking: 24/86, Q2, I.F.= 4.200, Chemistry, Analytical)
  8. Didem Rodoplu, Cherng–Shyang Chang, Cheng–Yuan Kao, and Chia-Hsien Hsu, “A micro-pupil device for point-of-care testing of viable Escherichia coli in tap water”, Microchemical Journal 178, 107390 (July. 1nst, 2022). (Ranking: 17/86, Q1, I.F.=4.800, Chemistry, Analytical). Corresponding Author
  9. Didem Rodoplu, Jefunnie Sierra Matahum, and Chia-Hsien Hsu, “A microfluidic hanging drop-based spheroid co-culture platform for probing tumor-angiogenesis”, Lab On A Chip 22, 1275-1285 (Feb. 22nd, 2022). (Ranking: 6/79, Q1, I.F.=8.368, Biochemical Research Methods). (Front Cover). Corresponding Author
  10. Chuan-Feng Yeh, Duane S. Juang, Ya-Wen Chen, Didem Rodoplu, Chia-Hsien Hsu*, “A Portable Controllable Compressive Stress Device to Monitor Cancer Cell Protrusions at Single-Cell Resolution”, Frontiers in Bioengineering and Biotechnology 10: 852318 (Feb. 24th, 2022). (Ranking: 16/73, Q1, I.F.= 6.303, Multidisciplinary Sciences). Corresponding Author
  11. Cheng-Kun He and Chia-Hsien Hsu, “Microfluidic technology for multiple single-cell capture”, Biomicrofluidics 15 (6):061501 (Nov. 8th, 2021). (Ranking: 12/34, I.F.= 3.128, Physics, Fluids & Plasmas). Corresponding Author
  12. Didem Rodoplu, Cherng-Shyang Chang, Cheng-Yuan Kao and Chia-Hsien Hsu, “A simple magnetic-assisted microfluidic method for rapid detection and phenotypic characterization of ultralow concentrations of bacteria”, Talanta 230 (2021) 12291 (August 1st, 2021). (Ranking: 11/87, Q1, I.F.=5.770, Chemistry, Analytical). (Front Cover). Corresponding Author
  13. Tugba Tezcan and Chia-Hsien Hsu, “High-sensitivity SERS based sensing on the labeling side of glass slides using low branched gold nanoparticles prepared with surfactant-free synthesis”, RSC Advances 10: 34290-34298 (September 18th, 2020). (Ranking: 75/179, Q2, I.F.=3.748, Chemistry, Multidisciplinary). Corresponding Author
  14. Chuan-Feng Yeh, Ching-Hui Lin, Hao-Chen Chang, Chia-Yu Tang, Pei-Tzu Lia, and Chia-Hsien Hsu, “A Microfluidic Single-Cell Cloning (SCC) Device for the Generation of Monoclonal Cells”, Cells 9 (6): E1482 (June. 18th, 2020). (Ranking: 51/194, Q2, I.F.=7.677, Cell Biology). Corresponding Author
  15. Yu-Lin Su, Li-Wen Kuo, Chia-Hsien Hsu, Chi-Shiun Chiang, Yu-Jen Lu, Shing-Jyh Chang, Shang-Hsiu Hu, “Rabies virus glycoprotein-amplified hierarchical targeted hybrids capable of magneto-electric penetration delivery to orthotopic brain tumor”, Journal of Controlled Release 321(10): 159-173 (Feb. 8th, 2020). (Ranking: 12/279,Q1 , I.F.=11.371, Pharmacology & Pharmacy)
  16. Hung Ji Huang, Yu-Cheng Chiang, Chia-Hsien Hsu, Jyh-Jian Chen, Ming-Hua Shiao, Chih-Chieh Yeh, Shu-Ling Huang, and Yung-Sheng Lin, “Light Energy Conversion Surface with Gold Dendritic Nanoforests/Si Chip for Plasmonic Polymerase Chain Reaction”, Sensors 27; 20(5): E1293 (Feb. 27th, 2020). (Ranking: 19/64, Q2, I.F.= 4.050, Instruments & Instrumentation)
  17. Ming-Yen Hsiao, An-Ci Lin, Wei-Hao Liao, Tyng-Guey Wang, Chia-Hsien Hsu, Wen-Shiang Chen and Feng-Huei Lin, “Drug-loaded hyaluronic acid hydrogel as a sustained-release regimen with dual effects in early intervention of tendinopathy”, Scientific Reports 18; 9(1): 4784 (Mar., 2019). (Ranking: 19/73, Q2, I.F.=5.516, Multidisciplinary Sciences)
  18. Cheng-Kun He, Ya-Wen Chen, Ssu-Han Wang and Chia-Hsien Hsu, “Establishing Single-Cell Based Co-Cultures in a Deterministic Manner with a Microfluidic Chip”, JoVE– Journal of Visualized Experiments 151: e60202 (Sep. 27th, 2019). (Ranking: 51/73, Q3, I.F.= 1.789, Multidisciplinary Sciences). Corresponding Author
  19. Hao-Chen Chang, Ching-Hui Lin, Duane S, Juang, Huei-Wen Wu, Che-Yen Lee, Chihchen Chen and Chia-Hsien Hsu, “Multilayer architecture microfluidic network array for combinatorial drug testing on 3D-cultured cells”, Biofabrication 19: 1370-1377 (May. 3rd, 2019). (Ranking: 9/98, Q1, I.F.=11.781, Engineering, Biomedical) . Corresponding Author
  20. Shou-Yu Ma, Yu-Cheng Chiang, Chia-Hsien Hsu, Jyh-Jian Chen, Chin-Chi Hsu, An-Chong Chao, and Yung-Sheng Lin, “Peanut Detection Using Droplet Microfluidic Polymerase Chain Reaction Device”, Journal of Sensors (May, 2019). (Ranking: 37/64, Q3, I.F.=2.564, Instruments & Instrumentation)
  21. Cheng-Kun He, Ya-Wen Chen, Ssu-Han Wang and Chia-Hsien Hsu, “Hydrodynamic shuttling for deterministic high-efficiency multiple single-cell capture in a microfluidic chip”, Lab On A Chip 19: 1370-1377 (Apr. 9th, 2019). (Ranking: 6/79, Q1, I.F.=8.368, Biochemical Research Methods). (Inside Back Cover). Corresponding Author
  22. Hsiao, Ming-Yen, Lin, Ping-Cheng, Liao, Wei-Hao, Chen, Wen-Shiang, Hsu, Chia-Hsien, He, Cheng-Kun, Wu, Ya-Wen, Gefen, Amit, Iafisco, Michele, Liu, Lixin, Lin, Feng-Huei, “The effect of the repression of oxidative stress on tenocyte differentiation: A preliminary study of a rat cell model using a novel differential tensile strain bioreactor”, International Journal of Molecular Sciences 20(14): 3437 (July 12th, 2019). (Ranking: 69/296, Q1, I.F.=6.628, Chemistry & Molecular Biology)
  23. I.-C. Young, S.-T. Chuang, A. Gefen, W.-.T Kuo, C.-T. Yang, C.-H. Hsu, F.-H. Lin, “A novel compressive stress-based osteoarthritis-like chondrocyte system”, Experimental Biology and Medicine 242(10): 1062-1017 (2017). (Ranking: 76/139, Q3, I.F.=4.561, Medicine, Research & Experimental)
  24. S. I. Yeh, C. C. Hau, C. J. Huang, H. C. Chang, C. H. Hsu, J. T. Yang, “Development of a simple static microwell array with uniform cell seeding and a chemical concentration gradient”, Microfluidics and Nanofluidics 21(5): 80 (2017). (Ranking: 23/64, Q2, I.F.=2.860, Instruments & Instrumentation)
  25. In-Chi Young, Sung-Ting Chuang, Chia-Hsien Hsu, Yu-Jun Sun, Hwa-Chang Liu, Yo-Shen Chen, and Feng-Huei Lin, “Protective effects of aucubin on osteoarthritic chondrocyte model induced by hydrogen peroxide and mechanical stimulus”, BMC Complementary and Alternative Medicine 17(1): 91 (2017). (Ranking: 5/30, Q1, I.F.=4.479, Integrative & Complementary Medicine)
  26. Young, I.-C., Chuang S.-T., Hsu, C.-H., Sun, Y.-J., Lin, F.-H., “C-phycocyanin alleviates osteoarthritic injury in chondrocytes stimulated with H2O2 and compressive stress”, International Journal of Biological Macromolecules 93 (Pt A): 852-859 (2016). (Ranking: 6/90, Q1, I.F.=7.626, Polymer Science)
  27. Hao-Chen Chang, Chia-Yu Tang, Hui-Ying Lin and Chia-Hsien Hsu*, “Microfluidic Tumor-mimicking In Vitro Cell Culture Methods”, International Journal of Automation and Smart Technology 6: no. 4 (2016)
  28. Yi-Hsing Hsiao, Chao-Yang Huang, Chih-Yung Hu, Yen-Yu Wu, Chung-Hsiun Wu, Chia-Hsien Hsu, Chihchen Chen, “Continuous microfluidic assortment of interactive ligands (CMAIL)”, Scientific Reports 6: 32454 (2016). (Ranking: 19/73, Q2, I.F.=5.516, Multidisciplinary Sciences)
  29. Wu, Huei-Wen; Hsiao, Yi-Hsing; Chen, Chih-Chen; Yet, Shaw-Fang; Hsu, Chia-Hsien, “A PDMS-Based Microfluidic Hanging Drop Chip for Embryoid Body Formation”, Molecules 21: no. 7: 882 (2016). (Ranking: 65/179, Q2, I.F.=5.110, Chemistry, Multidisciplinary). Corresponding Author
  30. Yi-Hsing Hsiao, Chia-Hsien Hsu, Chihchen Chen, “A High-Throughput Automated Microfluidic Platform for Calcium Imaging of Taste Sensing”, Molecules 21: no. 7: 896 (2016). (Ranking: 65/179, Q2, I.F.=5.110, Chemistry, Multidisciplinary)
  31. Duane S. Juang and Chia-Hsien Hsu, “Self-concentrating buoyant glass microbubbles for high sensitivity immunoassays”, Lab On A Chip 16: 459-464 (Feb. 7th, 2016). (Ranking: 6/79, Q1, I.F.=8.368, Biochemical Research Methods). (Inside Front Cover). Corresponding Author
  32. Ching-Hui Lin, Hao-Chen Chang and Chia-Hsien Hsu, “A microfluidic platform for high-throughput single-cell isolation and culture”, JoVE– Journal of Visualized Experiments 112: e54105 (2016). (Ranking: 51/73, Q3, I.F.= 1.789, Multidisciplinary Sciences). Corresponding Author

National Health Research Institutes – Institutional Repository: 5079

Patents

Title 專利名稱Patent number 專利號碼Inventors 專利發明人
微流體晶片及其於連續監測細菌的運動、生長和型態檢測之應用I898607許佳賢、羅明心
単一細胞収集方法7678741Chia-Hsien Hsu, Chuan-Feng Yeh
High-efficiency single-cell collection methodUS12011712 B2Chia-Hsien Hsu, Chuan-Feng Yeh
高效的單細胞採集方法I805068許佳賢、葉鵑鳳
Selective Particles transfer from one device to anotherUS11384326Hsu, Chia-Hsien, Lin, Ching-Hui, Juang, Duane S. Chang, Hao-Chen
A Microfluidic hydrodynamic shuttling chip device for highthroughput multiple single cells capturePAT 88891W-1Chia-Hsien Hsu
Microfluidic hydrodynamic shuttling chip device for highthroughput multiple single cells captureUS10946381Chia-Hsien Hsu
A Microfluidic Hydrodynamic Shuttling Chip Device for Highthroughput Multiple Single Cells Capture6839173Chia-Hsien Hsu
用於高通量多數單細胞捕獲之微流體動力式轉運晶片ZL201680047866許佳賢
Selective Particles transfer from one device to another11201804235yJuang, Duane S., Hsu, Chia-Hsien, Lin, Ching-Hui, Chang, Hao-Chen
轉移標的粒子之裝置及其方法I655283許佳賢、林璟暉、莊堵安、張浩禎
差別週期形變牽拉之細胞培養系統I648399林峯輝、蕭名彥, 陳文翔、許佳賢、林秉辰
Microfluidic Dual-well Device for Highthroughput Single-cell Capture and CultureUS10000732C.-H. Hsu, C.-H. Lin, H.-C. Chang, and I.-M. Chiu
流體動力式轉運晶片及其用於單細胞捕獲之方法I598587許佳賢
有興趣之生物物質的收集與濃縮系統及其應用I596327張瑛芝、許佳賢
單細胞擷取與培養之裝置與方法I588256許佳賢、林璟暉、莊堵安、張浩禎、邱英明
Collection and Concentration System for Biologic Substance of Interest and Use ThereofUS9494500Ying-Chih Chang and Chia-Hsien Hsu
Microfluidic hanging drop chipUS9034636C.-H. Hsu, and C.-C. Chen
Capturing ParticlesUS9128091Mehmet Toner, Shannon Stott, and Chia-Hsien Hsu
微流體懸吊液珠晶片I444473許佳賢、陳致真

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